human tissue Models

LIVER | GBM | More

Our models are available through early-access collaborations with qualified partners.

Liver Tissue Models

Drug response and metabolism testing for preclinical research
Personalized liver models (iPSC compatible)
High-throughput liver screening platforms

TissueGenix's advanced human liver models are developed for drug screening and personalized medicine. Our liver models can recapitulate the cell composition, density, and interactions under physiological and pathological conditions. To address different research needs, we have developed two human liver tissue models: iPSC-based multicellular micro-liver (mLiver) and high-cell-density liver (hLiver). Contact us for more details about the model.

Multicellular micro-liver (mLiver) model

The mLiver model is an iPSC-based 3D in vitro model recapitulating the highly vascularized multicellular hepatic microenvironment. The mLiver model displays strong biological relevance including hepatic marker expression, albumin and urea secretion, and liver metabolic activities. It can also be modified to model hepatic malignancy. This model is ideal for high-throughput drug screening and toxicity test.

High-cell-density liver (hLiver) model

The hLiver model is a dense bioprinted liver tissue with a high cell density (over 8 × 107 cells/mL). With enhanced cell-cell interactions, the hLiver model shows improved liver function, elevated metabolic activities, and physiological drug responses. This model can support high-throughput drug screening and toxicity test.

Glioblastoma Oncology Models

High-throughput drug and cell therapy screening
Convenient microenvironment study platform
Personalized models (patient-derived cell compatible)

Glioblastoma (GBM) is the most common and deadliest primary brain tumor in adults, known for frequent recurrence and poor prognosis. To help address the need for pathologically relevant GBM models, TissueGenix has developed GBM platforms designed to reflect key features of the native tumor microenvironment and capture major mechanisms that drive disease behavior. We offer two GBM model platforms for our customers: the Multicellular GBM (mGBM) model and the Stiffness‑Modulated GBM (sGBM) model. Both models are built to support high-throughput compound screening and mechanistic study. Contact use for more info.

Multicellular GBM (mGBM) model

The mGBM model recreates the multicellular, immunosuppressive GBM microenvironment in vitro. With patient-derived GBM cells, the model can capture patient-specific molecular signatures, tumor invasion, and drug resistance*. This versatile system supports high-throughput screening for chemotherapy and cell therapy products, as well as CRISPR screening and potency assays.

*The performance is subject to the use of patient-derived cell line. Contact us for details.

Stiffness‑Modulated GBM (sGBM)

The sGBM model is a scalable angiogenic GBM micro-model with tunable extracellular matrix (ECM) stiffness. Its unique design enables direct observation of stromal invasion and angiogenesis and supports visualization of lymphocyte trafficking and biophysical drug screening.